Someone to Talk To
Published:
李作杰
- 年龄：29
- 籍贯: 山东泰安
- 政治面貌：中共党员
- 工作地点：北京师范大学化学学院（放射性药物教育部重点实验室）＆物理与天文学院（放射线束教育部重点实验室），博士后
研究方向
- 计算机辅助药物设计
- 同源建模
- 结构设计优化
- 分子动力学模拟
- 抗肿瘤药物
- 靶点筛选及分子设计合成
- 生物活性测试及作用机制研究
- 药物制剂
- 放射性药物
- PET
- SPECT
教育经历
- 2015.09-2019.06 聊城大学 生物工程 工学学士
- 2019.09-2022.06 聊城大学 生物化学与分子工程 理学硕士
- 2022.09-2025.06 北京师范大学 药物化学与分子工程 理学博士
- 2025.07- 北京师范大学 物理学 博士后
工作经历
- 2017.10-2017.11 华润雪花 见习
- 2018.12-2019.01 恒瑞医药 见习
- 2019.02-2019.07 新和成药业 见习
已发表论文 (独立一作)
- J Med Chem, 2026, 69(5): 5887–5900.
- J Med Chem, 2025, 68(21): 23620-23631.
- J Med Chem, 2024, 67(24): 21644-21670.
- J Med Chem, 2024, 67(23): 21617-21628.
- J Med Chem, 2021, 64(24): 17920-17935.
- Mol Pharm, 2024, 21(10): 5305-5314.
- Dalton Trans, 2022, 51(33): 12604-12619.
- Dalton Trans, 2021, 50(1):362-375.
- Mini Rew Med Chem , 2025, 25(17), 1321-1333.
- Monatsh Chem, 2020, 151(3): 353-367.
- J Liaocheng Univ , 2020, 33(5): 97-103.
奖项荣誉
- 2020.05 聊城大学优秀学生干部
- 2022.06 聊城大学研究生优秀成果一等奖
- 2023.05 北京师范大学第四届研究生学术会议墙报一等奖
- 2025.04 第十七届全国放射性药物与标记化合物学术交流会优秀壁报
- 2025.05 原子高科博士生奖学金
Posts
Difficulty in calming the mind
Published:
portfolio
JMC封面文章（Front Cover）
Design, Synthesis and Evaluation of 99mTc Labelled Aminoadipic Acid-urea-Lysine (AuK) as a Novel SPECT Tracer Targeting PSMA
墙报：新型99mTc标记靶向PSMA的二聚体肿瘤显像剂的设计、合成与生物评价研究
第十七届全国放射性药物与标记化合物学术交流会优秀壁报
墙报：具有肿瘤微环境炎症抑制能力的铂（IV）配合物的设计合成及抗肿瘤机制研究
北京师范大学化学学院第四届研究生学术会议墙报一等奖
publications
Naphthalimide Platinum(IV) Compounds as Antitumor Agents with Dual DNA Damage Mechanism to Overcome Cisplatin Resistance
Published in 中原药学国际论坛,郑州, 2019
Recommended citation: 李作杰, 陈延，王庆鹏*
Download Paper
Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response
Published in Journal of Medicinal Chemistry, 2021
Zuojie Li, Qingpeng Wang, Linming Li, Yan Chen, Jichun Cui, Min Liu, Ning Zhang, Zhifang Liu, Jun Han, Zhengping Wang
Recommended citation: J Med Chem. 2021,64(24),17920-17935.
Download Paper | Download Slides
Synthesis and Evaluation of 99mTc-Labeled L-Aspartic Acid as a EuK Polymer Linker for Targeting PSMA to a Novel SPECT Tumor Tracer
Published in Journal of Medicinal Chemistry, 2024
Zuojie Li, Xiaojiang Duan, Peiwen Han, Guangxing Yin, Yuhao Jiang , Qing Ruan , Junbo Zhang
Recommended citation: J Med Chem. 2024,67(23),21617-21628.
Download Paper | Download Slides
Current Status and Perspectives of Novel Radiopharmaceuticals with Heterologous Dual-targeted Functions: 2013-2023.
Published in Journal of Medicinal Chemistry, 2024
Zuojie Li, Qing Ruan, Yuhao Jiang, Qianna Wang, Guangxing Yin, Junhong Feng, Junbo Zhang
Recommended citation: J Med Chem. 2024,67(24),21644-21670.
Download Paper | Download Slides
计算机辅助药物设计在[99mTc]Tc-CN7DG研究中的应用
Published in 第十七届全国放射性药物与标记化合物学术交流会,西安, 2025
Recommended citation: 李作杰, 张俊波*
Download Paper
Design, Synthesis, and Evaluation of a Novel 99mTc-Labeled Small Molecule Inhibitor (Lapatinib)-Based SPECT Tracer Targeting HER2
Published in Journal of Medicinal Chemistry, 2025
Zuojie Li, Lina Diao, Peiwen Han, Qingna Xiao, Dajie Ding, Junhong Feng, Jianyong Jiang, Junbo Zhang
Recommended citation: J Med Chem. 2025,68(21),23620-23631.
Download Paper | Download Slides
Design, Synthesis and Evaluation of 99mTc Labelled Aminoadipic Acid-urea-Lysine (AuK) as a Novel SPECT Tracer Targeting PSMA
Published in Journal of Medicinal Chemistry （Front Cover）, 2025
Zuojie Li, Peiwen Han, Lina Diao, Jianyong Jiang, Junbo Zhang
Recommended citation: J Med Chem. 2026,69(5),5887–5900.
Download Paper | Download Slides
talks
X-MOL:北京师范大学JMC综述-异源双靶向放射性药物的现状与展望：2013-2023
Published:
teaching
分子动力学模拟
Molecular Dynamics Simulation Tutorial, B站, 2025
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分子动力学模拟结果后处理
Energy, conformation, interaction, protein-ligand complex, B站, 2025
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